Journal article
Risk Factors and Prognosis of Early Posttraumatic Seizures in Moderate to Severe Traumatic Brain Injury
J Laing, B Gabbe, Z Chen, P Perucca, P Kwan, TJ O'Brien
JAMA Neurology | AMER MEDICAL ASSOC | Published : 2022
Abstract
IMPORTANCE Early posttraumatic seizures (EPS) that may occur following a traumatic brain injury (TBI) are associated with poorer outcomes and development of posttraumatic epilepsy (PTE). OBJECTIVE To evaluate risk factors for EPS, associated morbidity and mortality, and contribution to PTE. DESIGN, SETTING, AND PARTICIPANTS Data were collected from an Australian registry-based cohort study of adults (age ≥18 years) with moderate to severe TBI from January 2005 to December 2019, with 2-year follow-up. The statewide trauma registry, conducted on an opt-out basis in Victoria (population 6.5 million), had 15 152 patients with moderate to severe TBI identified via Abbreviated Injury Scale (AIS) h..
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Awarded by Epilepsy Foundation of Victoria
Funding Acknowledgements
The Victorian State Trauma Registry is funded by the Department of Health, State Government of Victoria, and Transport Accident Commission. Dr Laing is supported by a National Health and Medical Research Council (NHMRC) PhD scholarship (APP1169386) and the Brain Foundation. Dr Gabbe is supported by an Australian Research Council Future Fellowship (FT170100048). Dr Chen is supported by an Early Career Fellowship from the NHMRC of Australia (GNT1156444). Dr Perucca is supported by the NHMRC (APP1163708), Epilepsy Foundation, University of Melbourne, Monash University, Brain Australia, andWeary Dunlop Medical Research Foundation. Dr Kwan is supported by a Medical Research Future Fund Practitioner Fellowship (MRF1136427). Dr O'Brien is supported by a NHMRC Investigator Grant (APP1176426).